主要科研项目及成果 |
近年来主要从事生物医药及生物化工相关领域研究，主持或参与包括国家重点研发计划、国家自然科学基金、省自然科学基金等多个科研项目；发表SCI、EI论文二十余篇，申请并获得授权国家发明专利十余项。主要从事化员工物学与制药工程相关专业课程教学，指导员工参加全国大学制药工程设计竞赛、全国互联网+老员工创新创业大赛、国际基因工程机器大赛（IGEM）获得金奖、国家级奖项多个，获得校级教学成果奖三等奖一项，本科生导师制“优秀指导教师”一次，本科生优秀毕业论文指导教师一次。 近期承担项目经历： 1、国家重点研发计划政府间国际科技创新合作重点专项任务，2023.8-2026.9，2023YFE0100573，40万，在研，主持。 2、安徽省教育厅重点研究项目，2023.8-2025.9，2023AH051127，10万，在研，主持。 3、安徽省自然科学基金青年项目，2021.1-2022.12，2108085QB85，10万，在研，主持。 4、国家自然科学基金面上项目，2020.1-2023.12，21978001，参与。 5、国家重点研发计划政府间国际科技创新合作重点专项任务，2020.12-2023.11，2019YFE0123100，参与。 6、国家自然科学基金青年基金项目，2019.1-2021.12，51808003，参与。 7、企业横向，2023.1-2025.12，RH2300000567，5万元，在研，主持。 8、ufc下注APP官方网站校青年基金，2018.1-2018.12，RD17100193，主持。 9、中央高校基本科研专项资金重点项目，2014.1-2014.12，ZD2014YX0027，参与。 10、江苏省自然科学基金面上项目，2013.1-2015.12， BK2012763，参与。 近期发表的科研论文: [1] Xiangxiang Wang, Shuang He, Kaiye Wang, Xin Wang, Tingyuan Yan, Tingxuan Yan*, Zhixiang Wang*, Fabrication of betamethasone micro- and nanoparticles using supercritical antisolvent technology: In vitro drug release study and Caco-2 cell cytotoxicity evaluation, European Journal of Pharmaceutical Sciences, 2023, 181, 106341. [2] Congcong Wang, Tingyuan Yan, Tingxuan Yan*, Zhixiang Wang*, Fabrication of hesperetin/hydroxypropyl-β-cyclodextrin complex nanoparticles for enhancement of bioactivity using supercritical antisolvent technology, Journal of Molecular Structure, 2023, 1279, 134947. [3] Tingxuan Yan*, Haili Wang, Xingfang Song, Tingyuan Yan, Yuwen Ding, Kang Luo, Juan Zhen, Gui He, Libin Nian, Shuangshou Wang*, Zhixiang Wang*, Fabrication of apigenin nanoparticles using antisolvent crystallization technology: A comparison of supercritical antisolvent, ultrasonic-assisted liquid antisolvent, and high-pressure homogenization technologies, International Journal of Pharmaceutics, 2022, 624, 121981. [4] Shuangshou Wang*, Lu Zhang, Qiwen Jin, Zhongqiu Xu, Jiayi Zhao, Yuwen Ding, Wenzhi Li,Peng Lin, Jing Gu, Qi Zhang*, Yang Chen, Hongmei Chen, Tingxuan Yan*, Filter paper-based colorimetric analysis: An instrument-free strategy for semiquantitative naked-eye detection of food colorants, Food Chemistry, 2022, 390, 133087. [5] Shuangshou Wang*, Yuwen Ding, Haili Wang, Wenzhi Li, Wenjing Xu, Panwen Sun, Wei Huang, Yang Chen*, Jing Gu, Peng Lin, Liang Ma, Zi Liu, Qiang Ling, Qi Zhang, Hongmei Chen, Tingxuan Yan*, Molecularly imprinted upconversion nanoparticles for active tumor targeting and microinvasive photothermal therapy, Journal of Materials Science, 2022, 57, 5177-5197. [6] Shuailing Gu, Tingxuan Yan, Zongtao Zuo, Qiang Shao, Biao Wang, Xinlong Li, Fanhui Geng, Kai Zhang, Xia Xu, Jian Xu*, Polyurethane foam from grape-seed-based polyol, Green Materials, 2022. https://doi.org/10.1680/jgrma.21.00022 [7] Tingxuan Yan, Yuting Tao, Xiangxiang Wang, Changling Lv, Guizhi Miao, Shuangshou Wang*, Deqiang Wang*, Zhixiang Wang*, Preparation, characterization and evaluation of the antioxidant capacity and antitumor activity of myricetin microparticles formated by supercritical antisolvent technology, The Journal of Supercritical Fluids, 2021, 175, 105290. [8] Wei Wang, Haijun Wu, Usama Shakeel, Chao Wang, Tingxuan Yan, Xia Xu, Jian Xu*, Synergistic effect of acidity balance and hydrothermal pretreatment severity on alkali extraction of hemicelluloses from corn stalk, Biomass Conversion and Biorefinery. 2022, 12, 459-468. [9] Tingxuan Yan*, Mengru Ji, Yuxi Sun, Tingyuan Yan, Jie Zhao, Huiwen Zhang, Zhixiang Wang*, Preparation and characterization of baicalein/ hydroxypropyl-β-cyclodextrin inclusion complex for enhancement of solubility, antioxidant activity and antibacterial activity using supercritical antisolvent technology, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2020, 96, 285–295. [10] Tingyuan Yan, Yi Zhang, Mengru Ji, Zhixiang Wang, Tingxuan Yan*, Preparation of irbesartan composite microparticles by supercritical aerosol solvent extraction system for dissolution enhancement, The Journal of Supercritical Fluids, 2019, 153, 104594. [11] Shuangshou Wang, Wenzhi Li, Zhihong Yuan, Qiwen Jin, Zongpeng Ding, Xiaomeng Liu, Mingfu Ye, Jing Gu, Tingxuan Yan, Hongmei Chen, Yang Chen, Semiquantitative naked-eye detection of synthetic food colorants using highly-branched pipette tip as an all-in-one device, Analytica Chimica Act, 2022, 1211, 339901. [12] Deqiang Wang*, Deguo Wang, Tingxuan Yan, Weifeng Jiang, Xinya Han, Jvfen Yan, Yanrong Guo, Nanostructures assembly and the property of polysaccharide extracted from Tremella Fuciformis fruiting body. International Journal of Biological Macromolecules, 2019, 137: 751-760. [13] Liang Zhang, Liang Ma, TingxuanYan, Xinya Han, Jiandong Xu, Jian Xu, Xia Xu, Activated mitochondrial apoptosis in hESCs after dissociation involving the PKA/p-p53/Bax signaling pathway, Experimental Cell Research, 2018, 369(2): 226-233. [14] Tingxuan Yan, Yue Cheng, Zhixiang Wang, Dechun Huang, Honggang Miao, Yi Zhang, Prearation and characterization of baicalein powder micronized by the SEDS process, The Journal of Supercritical Fluids, 2015, 104: 177-182. [15] Yankai Fu, Tingxuan Yan, Xia Xu*. Insight of Transmembrane Processes of Self-Assembling Nanotubes Based on a Cyclic Peptide Using Coarse Grained Molecular Dynamics Simulation, Journal of Physical Chemistry B, 2017, 121(38): 9006-9012. [16] Mengyao Yang, Muhammad Saif Ur Rehman, Tingxuan Yan, Asad Ullah Khan, Piotr Oleskowicz-Popiel, Xia Xu, Ping Cui, Jian Xu*, Treatment of different parts of corn stover for high yield and lower polydispersity lignin extraction with high-boiling alkaline solvent, Bioresource Technology, 2017, 249: 737-743. [17] 颜庭轩，王志祥*，黄德春，宋杏芳. 超临界流体技术制备辛 伐他汀/PLLA-PEG缓释复合微球，高校化学工程学报，2014，2（2）： 401- 406. （EI） 近期发明专利 [1] 颜庭轩; 徐霞; 徐建; 张二伟 ; 一种超临界压缩流体沉淀法制备雷公藤红素纳米颗粒的方法, 2018-1-29, 中国, ZL201810082477.7
[2] 颜庭轩; 王志祥; 张会文; 刘祥; 马亮; 韩新亚 ; 吗啡啉类酸性离子液体在超临界压缩流体沉淀法制备黄芩素微胶囊中的应用, 2017-6-16, 中国, ZL201710455554.4
[3] 颜庭轩; 季梦茹; 张会文; 赵海莲; 王德强; 马亮; 韩新亚; 严菊分 ; 一种黑枸杞中总黄酮、提取方法、应用 , 2019-12-12, 中国, ZL201911288532.9
[4] 颜庭轩; 宋杏芳; 王双寿; 韩新亚; 卞金磊; 年礼斌; 张瑞盈 ; 一种超声协同高压均质技术制备芹菜素超细颗粒的方法, 2021-10-25, 中国, CN202111239933.2
[5] 颜庭轩; 孙玉玺; 徐霞; 马亮; 王肖肖; 王德强; 季梦茹; 赵海莲 ; 一种双靶向纳米微囊的制备方法及抗肿瘤应用, 2019-10-21, 中国, CN201910998097.2
[6] 颜庭轩; 徐霞; 陈艳; 张会文; 赵海莲; 马亮; 韩新亚; 严菊芬 ; 一种枇杷叶提取物纳米胶囊、制备方法及应用, 2019-12-12, 中国, CN201911274027.9
[7] 颜庭轩; 徐霞; 徐建; 张会文; 马亮; 袁亚梅 ; 一种提取银杏叶中双黄酮化合物的方法, 2018-9-26,中国, CN201811146323.6
[8] 颜庭轩; 苏嘉豪; 张林潇; 王誉; 王双寿; 韩新亚; 张羡康; 李韦诚; 方超；一种硼酸功能化 CdTe 量子点及肿瘤靶向诊疗一体化复合纳米药物，CN202311122035.8
[9] 徐霞; 张二伟; 颜庭轩; 张楷; 徐建 ; 一种基于低共熔溶剂为溶剂的包埋体系, 2018-03-14, 中国,ZL201810210882.2
[10] 马亮; 刘姿; 吴雨晴; 袁国赞; 徐霞; 徐建; 颜庭轩 ; 5,7-二溴-8-(甲氧甲氧基)-2-甲基喹啉或其药用盐在治疗乳腺癌中的应用, 2018-02-13, 中国, ZL201810149319.9 |
